The entire universe has no meanings at al whatsoever. It is our own minds that give the meaning to everything.
When nothing has true meaning, it follows that there is no fact in the world, either. Nietzsche once said there is no fact, only interpretations. We have been mistakenly regarded opinions as facts, and we torture ourselves as a result.
So, when we no longer regard opinions as facts, we are liberated. We no longer get mad when other people disagree with us. We stop trying hard to change other peoples beliefs. We then have time as well as energy to focus on improving ourselves. We listen more to other people. We feel happier.